This will serve as a guide as I quest.

Started on quest: 5,000
Goal: 500 quests
Amount on hand: 13,069,367MP
Started on 11/11/17 4:17
Number of Runes get: 41 Runes
5,017 Rune Q
5,028 Rune H
5,041 Rune Q
5,080 Rune A
5,084 Rune F
5,092 Rune E
5,093 Rune R
5,097 Rune F
5,110 Rune H
5,113 Rune AE
5,116 Rune D
5,118 Rune Z
5,149 Rune Q
5,155 Rune S
5,158 Rune H
5,166 Rune D
5,169 Rune U
5,186 Rune Z
5,190 Rune E
5,197 Rune B
5,205 Rune R
5,240 Rune AE
5,254 Rune D
5,257 Rune S
5,259 Rune E
5,284 Rune J
5,299 Rune W
Pausing at 5,300 8:51
Continued at 11/12/17 4:09
5,305 Rune O
5,313 Rune E
5,341 Rune Z
5,344 Rune E
5,346 Rune U
5,349 Rune T
5,356 Rune T
5,368 Rune Z
5,385 Rune A
5,410 Rune Q
5,427 Rune A
5,462 Rune M
5,476 Rune K
5,500 Rune S
Amount on hand after questing: 11,738,473MP
Total Amount Spent: 1,330,894MP
Total Value of Runes get: 14,436,040MP
Profit: 13,105,146MP
Finished on 11/12/17 6:12

[PS] I update as I quest.

Comments:
~Look for my other runs for statistics.
~I'd intended to do the 1k goal but because of an unexpected event, I didn't have the day to complete it so I can only do 500 again.
~This run is a success because I got 41 runes, which is what ideally want.
~The run where I spent the second least amount of MP possible.